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Graphical contents list • MISCELLANEOUS PDF (633 K) | |||
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Synthesis of 1H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors • SHORT COMMUNICATION Le Wang, Nan-Horng Lin, Qun Li, Rodger F. Henry, Haiying Zhang, Jerome Cohen, Wen-Zhen Gu, Kennan C. Marsh, Joy L. Bauch, Saul H. Rosenberg and Hing L. Sham SummaryPlus | Full Text + Links | PDF (304 K) | |||
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Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: Design, synthesis and structure–activity relationship studies • SHORT COMMUNICATION Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois, Nga Pham, Emmanuelle Proust, Chrystelle Oliveira, Abdel-Kader Mafroud, Frederique Royer, Roger Wrigglesworth, Jennifer Schellhaas et al. SummaryPlus | Full Text + Links | PDF (311 K) | |||
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Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivatives • SHORT COMMUNICATION Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois, Nga Pham, Emmanuelle Proust, Chrystelle Oliveira, Abdel-Kader Mafroud, Pierre Ducrot, Roger Wrigglesworth, Françoise Berlioz-Seux et al. SummaryPlus | Full Text + Links | PDF (308 K) | |||
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Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1 • SHORT COMMUNICATION Edwige Lorthiois, Patrick Bernardelli, Fabrice Vergne, Chrystelle Oliveira, Abdel-Kader Mafroud, Emmanuelle Proust, Lamia Heuze, François Moreau, Moulay Idrissi, Anita Tertre et al. SummaryPlus | Full Text + Links | PDF (271 K) | |||
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Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives • SHORT COMMUNICATION Patrick Bernardelli, Edwige Lorthiois, Fabrice Vergne, Chrystelle Oliveira, Abdel-Kader Mafroud, Emmanuelle Proust, Nga Pham, Pierre Ducrot, François Moreau, Moulay Idrissi et al. SummaryPlus | Full Text + Links | PDF (301 K) | |||
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In vitro anti-parasitic activity of Cyclosporin A analogs on Trypanosoma cruzi • SHORT COMMUNICATION Jacqueline Búa, Andrés M. Ruiz, Mariana Potenza and Laura E. Fichera SummaryPlus | Full Text + Links | PDF (307 K) | |||
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Synthesis and evaluation of tacrine–E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease • SHORT COMMUNICATION Dong Shao, Chunyan Zou, Cheng Luo, Xican Tang and Yuanchao Li SummaryPlus | Full Text + Links | PDF (321 K) | |||
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From triplex to B-form duplex stabilization: reversal of target selectivity by aminoglycoside dimers • SHORT COMMUNICATION Dev P. Arya, R. Lane Coffee, Jr. and Liang Xue SummaryPlus | Full Text + Links | PDF (340 K) | |||
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Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives • SHORT COMMUNICATION Vishal Arora, Manikrao M. Salunkhe, Neelima Sinha, Rakesh K. Sinha and Sanjay Jain SummaryPlus | Full Text + Links | PDF (261 K) | |||
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P1′ oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1 • SHORT COMMUNICATION Ronald M. Kim, Elizabeth A. Rouse, Kevin T. Chapman, William A. Schleif, David B. Olsen, Mark Stahlhut, Carrie A. Rutkowski, Emilio A. Emini and James R. Tata SummaryPlus | Full Text + Links | PDF (271 K) | |||
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Stereoselective synthesis of nicotinamide β-riboside and nucleoside analogs • SHORT COMMUNICATION Palmarisa Franchetti, Michela Pasqualini, Riccardo Petrelli, Massimo Ricciutelli, Patrizia Vita and Loredana Cappellacci SummaryPlus | Full Text + Links | PDF (271 K) | |||
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Synthesis and biological evaluation of stilbene-based pure estrogen antagonists • SHORT COMMUNICATION Georg Walter, Renate Liebl and Erwin von Angerer SummaryPlus | Full Text + Links | PDF (287 K) | |||
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Exploring QSAR with E-state index: selectivity requirements for COX-2 versus COX-1 binding of terphenyl methyl sulfones and sulfonamides • SHORT COMMUNICATION Santanu Chakraborty, Chandana Sengupta and Kunal Roy SummaryPlus | Full Text + Links | PDF (403 K) | |||
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GAsDock: a new approach for rapid flexible docking based on an improved multi-population genetic algorithm • SHORT COMMUNICATION Honglin Li, Chunlian Li, Chunshan Gui, Xiaomin Luo, Kaixian Chen, Jianhua Shen, Xicheng Wang and Hualiang Jiang SummaryPlus | Full Text + Links | PDF (349 K) | |||
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Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size • SHORT COMMUNICATION Sangku Lee, Jong-Min Han, Hyunjung Kim, Eungsoo Kim, Tae-Sook Jeong, Woo Song Lee and Kyung-Hyun Cho SummaryPlus | Full Text + Links | PDF (344 K) | |||
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Formation of 4,4′-dimethoxytrityl-C-phosphonate oligonucleotides • SHORT COMMUNICATION Daniel C. Capaldi, Hans J. Gaus, Recaldo L. Carty, Max N. Moore, Brett J. Turney, Stella D. Decottignies, James V. McArdle, Anthony N. Scozzari, Vasulinga T. Ravikumar and Achim H. Krotz SummaryPlus | Full Text + Links | PDF (405 K) | |||
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Markov entropy backbone electrostatic descriptors for predicting proteins biological activity • SHORT COMMUNICATION Humberto González-Dı́az, Reinaldo Molina and Eugenio Uriarte SummaryPlus | Full Text + Links | PDF (356 K) | |||
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2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands • SHORT COMMUNICATION Thomas Prisinzano, Małgorzata Dukat, Ho Law, Abdelmalik Slassi, Neil MacLean, Inés DeLannoy and Richard A. Glennon SummaryPlus | Full Text + Links | PDF (256 K) | |||
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Identification of a potent and rapidly reversible inhibitor of the 20S-proteasome • SHORT COMMUNICATION Ashok V. Purandare, Honghe Wan, Naomi Laing, Khalid Benbatoul, Wayne Vaccaro and Michael A. Poss SummaryPlus | Full Text + Links | PDF (279 K) | |||
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Long-chain formoterol analogues: an investigation into the effect of increasing amino-substituent chain length on the β2-adrenoceptor activity • SHORT COMMUNICATION Vahid Alikhani, David Beer, David Bentley, Ian Bruce, Bernard M. Cuenoud, Robin A. Fairhurst, Peter Gedeck, Sandra Haberthuer, Claire Hayden, Diana Janus et al. SummaryPlus | Full Text + Links | PDF (300 K) | |||
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Synthesis and structure–activity relationships of andrographolide analogues as novel cytotoxic agents • SHORT COMMUNICATION Srinivas Nanduri, Vijay Kumar Nyavanandi, Siva Sanjeeva Rao Thunuguntla, Sridevi Kasu, Mahesh Kumar Pallerla, P. Sai Ram, Sriram Rajagopal, R. Ajaya Kumar, Rajagopalan Ramanujam, J. Moses Babu et al. SummaryPlus | Full Text + Links | PDF (347 K) | |||
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Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation • SHORT COMMUNICATION Valeriy A. Bacherikov, Ting-Chao Chou, Hua-Jin Dong, Ching-Huang Chen, Yi-Wen Lin, Tsong-Jen Tsai and Tsann-Long Su SummaryPlus | Full Text + Links | PDF (258 K) | |||
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Triterpenoids. Part 21: Oleanolic acid azaderivatives as percutaneous transport promoters • SHORT COMMUNICATION Lucjusz Zaprutko, Danuta Partyka and Barbara Bednarczyk-Cwynar SummaryPlus | Full Text + Links | PDF (259 K) | |||
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3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase • SHORT COMMUNICATION Mark C. Noe, Sheri L. Snow, Lilli A. Wolf-Gouveia, Peter G. Mitchell, Lori Lopresti-Morrow, Lisa M. Reeves, Sue A. Yocum, Jennifer L. Liras and Marcie Vaughn SummaryPlus | Full Text + Links | PDF (266 K) | |||
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A novel cyclic enkephalin analogue with potent opioid antagonist activity • SHORT COMMUNICATION Grazyna Weltrowska, Yixin Lu, Carole Lemieux, Nga N. Chung and Peter W. Schiller SummaryPlus | Full Text + Links | PDF (252 K) | |||
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Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials • SHORT COMMUNICATION Lawrence B. Snyder, Zhaoxing Meng, Robert Mate, Stanley V. D’Andrea, Anne Marinier, Claude A. Quesnelle, Patrice Gill, Kenneth L. DenBleyker, Joan C. Fung-Tomc, MaryBeth Frosco et al. SummaryPlus | Full Text + Links | PDF (331 K) | |||
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Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors • SHORT COMMUNICATION Jeffrey A. Campbell, Viola Bordunov, Chris A. Broka, Michelle F. Browner, James M. Kress, Tara Mirzadegan, Chakk Ramesha, Bong F. Sanpablo, Russell Stabler, Patricia Takahara et al. SummaryPlus | Full Text + Links | PDF (419 K) | |||
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Pyridoxine as a template for the design of antiplatelet agents • SHORT COMMUNICATION Wenlian Zhang, John Yao, Vinh Pham, Tara Whitney, Doug Froese, Albert Friesen, Linda Stang, Chen Xu, Ashfaq Shuaib, James M. Diakur and Wasim Haque SummaryPlus | Full Text + Links | PDF (265 K) | |||
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2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents • SHORT COMMUNICATION Pei-Wen Hsieh, Fang-Rong Chang, Cheng-Hsien Chang, Pei-Wen Cheng, Lien-Chai Chiang, Fu-Long Zeng, Kuei-Hsiang Lin and Yang-Chang Wu SummaryPlus | Full Text + Links | PDF (262 K) | |||
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Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis • SHORT COMMUNICATION Zhenjiang Zhao, Yufang Xu, Zhigang Qian, Wenhong Tian, Xuhong Qian and Jian-Jiang Zhong SummaryPlus | Full Text + Links | PDF (273 K) | |||
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Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors • SHORT COMMUNICATION Jinyou Xu, Hyun O. Ok, Edward J. Gonzalez, Lawrence F. Colwell, Jr., Bahanu Habulihaz, Huaibing He, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio et al. SummaryPlus | Full Text + Links | PDF (257 K) | |||
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Substituted piperazines as novel dipeptidyl peptidase IV inhibitors • SHORT COMMUNICATION Linda L. Brockunier, Jiafang He, Lawrence F. Colwell, Jr., Bahanu Habulihaz, Huaibing He, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio, Reshma A. Patel et al. SummaryPlus | Full Text + Links | PDF (265 K) | |||
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Synthesis and biological evaluation of taxinine analogues as orally active multidrug resistance reversal agents in cancer • SHORT COMMUNICATION Xin Zhao, Jun Gu, Dali Yin and Xiaoguang Chen SummaryPlus | Full Text + Links | PDF (269 K) | |||
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The pharmacophore hypotheses of IKr potassium channel blockers: novel class III antiarrhythmic agents • SHORT COMMUNICATION Lü-Pei Du, Keng-Chang Tsai, Min-Yong Li, Qi-Dong You and Lin Xia SummaryPlus | Full Text + Links | PDF (376 K) | |||
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Design and synthesis of substituted N-methylbenzamide analogues derived from SR 48,968 as neurokinin-2 receptor antagonists • SHORT COMMUNICATION Shih-Chung Huang, Bradley Undem and Vijaya Korlipara SummaryPlus | Full Text + Links | PDF (270 K) | |||
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Formation of squaric acid amides of anthracycline antibiotics. Synthesis and cytotoxic properties • SHORT COMMUNICATION Anna Tevyashova, Ferenc Sztaricskai, Gyula Batta, Pál Herczegh and András Jeney SummaryPlus | Full Text + Links | PDF (283 K) | |||
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Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine–benzimidazole conjugates with remarkable DNA-binding affinity • SHORT COMMUNICATION Ahmed Kamal, P. Ramulu, O. Srinivas, G. Ramesh and P. Praveen Kumar SummaryPlus | Full Text + Links | PDF (294 K) | |||
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Topological estimation of electronic absorption bands of arene absorption spectra as a tool for modeling their toxicity and environmental pollution • SHORT COMMUNICATION Padmakar V. Khadikar, Shalini Singh, Mona Jaiswal and Dheeraj Mandloi SummaryPlus | Full Text + Links | PDF (296 K) | |||
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Editorial board • MISCELLANEOUS PDF (220 K) | |||
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Contributors to this issue • MISCELLANEOUS PDF (188 K) | |||
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Instructions to contributors • PUBLISHER'S NOTE PDF (74 K) | |||
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